Induction, vulval virus, preeclampsia and the perineum

Computational modeling of Caenorhabditis elegans vulval induction

MOTIVATION Caenorhabditis elegans vulval development is a paradigmatic example of animal organogenesis with extensive experimental data. During vulval induction, each of the six multipotent vulval precursor cells (VPCs) commits to one of three fates (primary, secondary, tertiary). The precise primary-secondary-tertiary formation of VPC fates is controlled by a network of intercellular signaling...

Anchor cell signaling and vulval precursor cell positioning establish a reproducible spatial context during C. elegans vulval induction.

How cells coordinate their spatial positioning through intercellular signaling events is poorly understood. Here we address this topic using Caenorhabditis elegans vulval patterning during which hypodermal vulval precursor cells (VPCs) adopt distinct cell fates determined by their relative positions to the gonadal anchor cell (AC). LIN-3/EGF signaling by the AC induces the central VPC, P6.p, to...

HPL-2/HP1 prevents inappropriate vulval induction in C. elegans by acting in both HYP7 and Vulval Precursor Cells

HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells.

A current model for Caenorhabditis elegans vulval cell fate specification is that SynMuv genes act redundantly in the hyp7 hypodermal syncytium to repress the LIN-3/EGF inducer and prevent ectopic vulval induction of vulva precursor cells (VPCs). Here we show that the SynMuv gene hpl-2/HP1 has an additional function in VPCs, where it may act through target genes including LIN-39/Hox.

Necrotizing Infection of the Perineum

Hospital Physician January 2008 39 S pontaneous gangrene of the scrotum was described for the first time in 1753 by Boerhaave,1 who reported on a 40-year-old man with urinary retention. Since that time, several authors have reported similar cases of spontaneous gangrene of the scrotum and penis with associated diseases such as systemic infections, diabetes, urinary extravasations and infiltrati...